Quantitative PCR analysis of salivary pathogen burden in periodontitis
Identifieur interne : 000D80 ( Main/Exploration ); précédent : 000D79; suivant : 000D81Quantitative PCR analysis of salivary pathogen burden in periodontitis
Auteurs : Aino Salminen [Finlande] ; K. A. Elisa Kopra [Finlande] ; Kati Hyv Rinen [Finlande] ; Susanna Paju [Finlande] ; P Ivi M Ntyl [Finlande] ; K Re Buhlin [Finlande, Suède] ; Markku S. Nieminen [Finlande] ; Juha Sinisalo [Finlande] ; Pirkko J. Pussinen [Finlande]Source :
- Frontiers in Cellular and Infection Microbiology [ 2235-2988 ] ; 2015.
Abstract
Our aim was to investigate the value of salivary concentrations of four major periodontal pathogens and their combination in diagnostics of periodontitis. The Parogene study included 462 dentate subjects (mean age 62.9 ± 9.2 years) with coronary artery disease (CAD) diagnosis who underwent an extensive clinical and radiographic oral examination. Salivary levels of four major periodontal bacteria were measured by quantitative real-time PCR (qPCR). Median salivary concentrations of
Url:
DOI: 10.3389/fcimb.2015.00069
PubMed: 26484315
PubMed Central: 4589666
Affiliations:
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Pussinen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital</institution><country>Helsinki, Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea></wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26484315</idno><idno type="pmc">4589666</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589666</idno><idno type="RBID">PMC:4589666</idno><idno type="doi">10.3389/fcimb.2015.00069</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000288</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000288</idno><idno type="wicri:Area/Pmc/Curation">000288</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000288</idno><idno type="wicri:Area/Pmc/Checkpoint">000B27</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B27</idno><idno type="wicri:Area/Ncbi/Merge">006040</idno><idno type="wicri:Area/Ncbi/Curation">006040</idno><idno type="wicri:Area/Ncbi/Checkpoint">006040</idno><idno type="wicri:Area/Main/Merge">000D82</idno><idno type="wicri:Area/Main/Curation">000D80</idno><idno type="wicri:Area/Main/Exploration">000D80</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Quantitative PCR analysis of salivary pathogen burden in periodontitis</title><author><name sortKey="Salminen, Aino" sort="Salminen, Aino" uniqKey="Salminen A" first="Aino" last="Salminen">Aino Salminen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital</institution><country>Helsinki, Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Kopra, K A Elisa" sort="Kopra, K A Elisa" uniqKey="Kopra K" first="K. A. Elisa" last="Kopra">K. A. Elisa Kopra</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital</institution><country>Helsinki, Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Hyv Rinen, Kati" sort="Hyv Rinen, Kati" uniqKey="Hyv Rinen K" first="Kati" last="Hyv Rinen">Kati Hyv Rinen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital</institution><country>Helsinki, Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Paju, Susanna" sort="Paju, Susanna" uniqKey="Paju S" first="Susanna" last="Paju">Susanna Paju</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital</institution><country>Helsinki, Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="M Ntyl, P Ivi" sort="M Ntyl, P Ivi" uniqKey="M Ntyl P" first="P Ivi" last="M Ntyl">P Ivi M Ntyl</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital</institution><country>Helsinki, Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Buhlin, K Re" sort="Buhlin, K Re" uniqKey="Buhlin K" first="K Re" last="Buhlin">K Re Buhlin</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital</institution><country>Helsinki, Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Division of Periodontology, Department of Dental Medicine, Karolinska Institutet</institution><country>Huddinge, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Cardiology, Heart and Lung Center, Department of Medicine, Helsinki University Hospital</institution><country>Helsinki, Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Cardiology, Heart and Lung Center, Department of Medicine, Helsinki University Hospital</institution><country>Helsinki, Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Pussinen, Pirkko J" sort="Pussinen, Pirkko J" uniqKey="Pussinen P" first="Pirkko J." last="Pussinen">Pirkko J. Pussinen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital</institution><country>Helsinki, Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Cellular and Infection Microbiology</title><idno type="eISSN">2235-2988</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Our aim was to investigate the value of salivary concentrations of four major periodontal pathogens and their combination in diagnostics of periodontitis. The Parogene study included 462 dentate subjects (mean age 62.9 ± 9.2 years) with coronary artery disease (CAD) diagnosis who underwent an extensive clinical and radiographic oral examination. Salivary levels of four major periodontal bacteria were measured by quantitative real-time PCR (qPCR). Median salivary concentrations of <italic>Porphyromonas gingivalis, Tannerella forsythia</italic>, and <italic>Prevotella intermedia</italic>, as well as the sum of the concentrations of the four bacteria, were higher in subjects with moderate to severe periodontitis compared to subjects with no to mild periodontitis. Median salivary <italic>Aggregatibacter actinomycetemcomitans</italic> concentrations did not differ significantly between the subjects with no to mild periodontitis and subjects with moderate to severe periodontitis. In logistic regression analysis adjusted for age, gender, diabetes, and the number of teeth and implants, high salivary concentrations of <italic>P. gingivalis, T. forsythia</italic>, and <italic>P. intermedia</italic> were significantly associated with moderate to severe periodontitis. When looking at different clinical and radiographic parameters of periodontitis, high concentrations of <italic>P. gingivalis</italic> and <italic>T. forsythia</italic> were significantly associated with the number of 4–5 mm periodontal pockets, ≥6 mm pockets, and alveolar bone loss (ABL). High level of <italic>T. forsythia</italic> was associated also with bleeding on probing (BOP). The combination of the four bacteria, i.e., the bacterial burden index, was associated with moderate to severe periodontitis with an odds ratio (OR) of 2.40 (95% CI 1.39–4.13). When <italic>A. actinomycetemcomitans</italic> was excluded from the combination of the bacteria, the OR was improved to 2.61 (95% CI 1.51–4.52). The highest OR 3.59 (95% CI 1.94–6.63) was achieved when <italic>P. intermedia</italic> was further excluded from the combination and only the levels of <italic>P. gingivalis</italic> and <italic>T. forsythia</italic> were used. Salivary diagnostics of periodontitis has potential especially in large-scale population studies and health promotion. The cumulative strategy appears to be useful in the analysis of salivary bacteria as markers of periodontitis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Boutaga, K" uniqKey="Boutaga K">K. Boutaga</name></author><author><name sortKey="Savelkoul, P H M" uniqKey="Savelkoul P">P. H. M. Savelkoul</name></author><author><name sortKey="Winkel, E G" uniqKey="Winkel E">E. G. Winkel</name></author><author><name sortKey="Van Winkelhoff, A J" uniqKey="Van Winkelhoff A">A. 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Camargo</name></author><author><name sortKey="Wong, D T" uniqKey="Wong D">D. T. Wong</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Finlande</li><li>Suède</li></country></list><tree><country name="Finlande"><noRegion><name sortKey="Salminen, Aino" sort="Salminen, Aino" uniqKey="Salminen A" first="Aino" last="Salminen">Aino Salminen</name></noRegion><name sortKey="Buhlin, K Re" sort="Buhlin, K Re" uniqKey="Buhlin K" first="K Re" last="Buhlin">K Re Buhlin</name><name sortKey="Hyv Rinen, Kati" sort="Hyv Rinen, Kati" uniqKey="Hyv Rinen K" first="Kati" last="Hyv Rinen">Kati Hyv Rinen</name><name sortKey="Kopra, K A Elisa" sort="Kopra, K A Elisa" uniqKey="Kopra K" first="K. A. Elisa" last="Kopra">K. A. Elisa Kopra</name><name sortKey="M Ntyl, P Ivi" sort="M Ntyl, P Ivi" uniqKey="M Ntyl P" first="P Ivi" last="M Ntyl">P Ivi M Ntyl</name><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name><name sortKey="Paju, Susanna" sort="Paju, Susanna" uniqKey="Paju S" first="Susanna" last="Paju">Susanna Paju</name><name sortKey="Pussinen, Pirkko J" sort="Pussinen, Pirkko J" uniqKey="Pussinen P" first="Pirkko J." last="Pussinen">Pirkko J. Pussinen</name><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name></country><country name="Suède"><noRegion><name sortKey="Buhlin, K Re" sort="Buhlin, K Re" uniqKey="Buhlin K" first="K Re" last="Buhlin">K Re Buhlin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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